Abstract: Clinical Analysis of 28 Cases of Pulmonary Mucoepidermoid CarcinomaZhansheng JIANG, Yanmin XING, Lan LAN, Guangru XIECorrespondence to: XIE Guangru, E-mail: xieguangru@126.comDepartment of Synergistic Chinese and Western Medicine Oncology, Cancer Institute and Hospital of Tianjin Medical Uni-versity; Key Laboratory of Cancer Prevention and Therapy in Tianjin, Tianjin 300060, ChinaAbstract Objective: To analyze the clinical and prognostic data of pulmonary mucoepidermoid carcinoma (PMEC), toconclude the progression in diagnosis and therapy of the disease in combination with literature review, and to provide thetheoretical basis for appropriate treatment. Methods: Clinical data of 28 patients with PMEC (confirmed by pathology) treat-ed in this hospital between January 1979 and December 2009 were retrospectively reviewed. There were 17 males and 4females, with an average age of 53 years, ranging from 16 to 73. Routine examinations were performed in patients, includ-ing alternative chest X-ray and CT examinations in all, and PET-CT scan in only one. Tumor on the right lung was found in15 cases and tumor on the left lung in the other 13. A total of 19 cases suffered from central type PMEC, and the others pe-ripheral type PMEC. Of the 22 patients who underwent a fiberoptic bronchoscopy, neoplasm was confirmed in 17. Surgicaltherapy was most common in 21 of the total 28 cases, and non-surgical treatment was given in 7. Results: All patients, ex-cept for only 2 patients with loss of visit, were completely followed up, with an average follow-up time of 53 months (ranged2 to 113 months). Until the deadline of the follow-up, incidence of death was found in 13 cases, including one in the phaseⅠand Ⅱ cases each, 7 in phase Ⅲ and 3 in phase Ⅳ cases, and one in the indefinite phase. Two of the 28 patients with ahistological grade of high malignancy died at 4 and 8 months respectively after the final diagnosis. The overall 1-, 3- and 5-year survival rates were 68.4%, 53.4% and 44.5% in the group, respectively. Conclusion: The incidence of PMEC is low inall lung cancers, lacking specific clinical representations. The final diagnosis mainly relies on the postoperative pathology.Surgery is the main treatment method. The prognosis of PMEC closely relates to the histological grading. Other factors in-clude pathological or clinical staging. Short-term recurrence and distant metastasis are also seen. The degree of malignan-cy remains to be determined compared with other types of lung cancers.Keywords Lung neoplasm; Mucoepidermoid carcinoma; Clinical features